EP PerMed (European Partnership for Personalised Medicine) - "Pharmacogenomic strategies for personalised medicine approaches"
Fond National de la Recherche Scientifique (F.R.S.-FNRS)
Aim of the call
With this call, EP PerMed will fund research projects in human health on pharmacogenomic strategies for PM approaches that address one or more of the following aspects:
• identification of new pharmacogenomic markers or signatures using (multi)-omics data in relation to drug or drug combination.
• validation of a pharmacogenomic marker or signatures using (multi)-omics data in predicting drug or drug combination outcomes.
• use pharmaco-omics strategies to determine the right dosage, the efficacy of treatments and/or the risk of adverse drug response and non-response to treatment to tailor personalised treatment pathways, including combined treatments (multi-medication).
Projects are encouraged to combine the following aspects in their research:
1. Omics data such as epigenomics, transcriptomics, proteomics and metabolomics data in addition to genomics data in relation to treatment outcomes. A key goal is to assess the importance of one or more -omics approaches (multi-modal approaches) in optimising treatment outcomes.
2. Information regarding patient medication (prescription and non-prescription), dose or compliance. 3. Information (including clinical and environmental factors) regarding medication efficacy, adverse effects and patient reported outcomes (PRO).
Please note:
• Research projects in all disease areas are welcome.
• Research on polygenic drug response phenotypes is encouraged.
• Projects focussing only on drug-drug-interaction are out of scope.
• Projects focusing on the clinical development of new drugs are out scope.
Financement
Each partner is funded separately by the national/regional funding organisation they are applying to. They must fulfil the conditions of their funding organisation.
The maximum amount of requested funding per project is 300.000 EUR for a total period of thee years. If the project involves the recruitment of a PhD student, the project duration of the F.R.S.-FNRS sub-project could be up to four years.
Eligible costs items
Personnel costs: 80,000€ EUR per year on average for the duration of the project. The usual duration of ERA-NET research programmes is three years. However, when the project involves a PhD student, the principal investigator can apply for an additional one year funding in order to complete the four years PhD programme. Since this programme is co-funded by the European Commission, this final year should not be included in the budget submitted to this call.
Equipment: can be eligible up to 20% of the total budget of the project
Running costs: travel expenses; organisation of small scientific events in Belgium; consumables and the following support costs: consumables Publication Designing (conception d’ouvrage) Dictionary Production (réalisation de dictionnaire) Purchase of Books Encoding Software Access Rights Congress Registration Fees Purchase of Computer Scanning Travel costs Visa costs Open Access publication of an article up until 500 euros (see F.R.S-FNRS Open Access policy).
“Overhead” is not an eligible cost for FNRS. If the project is selected for funding, these costs will be subject to a separate agreement between the institution of the beneficiary and the F.R.S.-FNRS.
Pour postuler
Submission of joint transnational proposals:
A two-step submission and evaluation procedure has been established for joint applications: pre-proposals and full-proposals.
Electronic proposal submission is mandatory on PT-Outline. Research project consortia who intend to submit a transnational proposal should register as soon as possible, by clicking on “Sign up” and follow further instructions.
Submission of F.R.S-FNRS proposal:
Applicants must provide basic administrative data by submitting an administrative application on e-space within 5 working days after the general deadline of the call to be eligible. Please select the “PINT-MULTI” funding instrument when creating the administrative application. This call follows a one-step procedure.
Deadlines:
Pre-proposal: February 18, 2025 at 14:00 CET
Full Proposals: June 17, 2025 at 14:00 CEST
e-space: February 25, 2025 at 14:00 (CEST)
Requis d'admission
Eligibility rules for the consortia
• Proposals must be interdisciplinary and clearly demonstrate the potential impact on disease outcome and prevention through personalised medicine, as well as the added value of the transnational collaboration
• Only transnational projects will be funded.
• Each consortium must involve at least three partners from three different EU Member States or Associated Countries whose funding organisations participate in the call. Each of these partners must be eligible and request funding from the respective funding organisation. All three legal entities must be independent of each other.
• The project coordinator (i.e. the principal investigator and the applicant’s organisation) must be eligible to be funded by his/her regional/national participating funding organisation. The project coordinator (i.e. principal investigator and organisation) cannot be changed between the first and second stage.
• Max. 2 project partners per consortium can request funding from the same funding organisation.
Eligibility rules for F.R.S. - FNRS
Applicants requesting funding from F.R.S. FNRS must comply with the following rules.
The applicant must be affiliated to a university from the Wallonia-Brussels Federation (FWB).
At the closure of the call, the applicant should also:
- Be a permanent researcher of F.R.S-FNRS (Chercheur qualifié, maître de recherches ou Directeur de recherche) or;
- Hold a tenure track position (or an assimilated position including pending tenure track) with a research institution from the FWB
After the submission of applications, the F.R.S.-FNRS and the research institutions are required to verify the eligibility of the candidates. The F.R.S.-FNRS reserves the right to refuse those whose eligibility criteria would not comply with the Regulation.
In order the check the compliance with these eligibility criteria, please contact your contact person at ULB-TTO (see details below). T
he complete F.R.S-FNRS rules for international research projects is available at the following link: https://www.frs-fnrs.be/docs/Reglement-et-documents/International/FRS-FNRS_PINT-Multi.pdf
Zones géographiques
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